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Playing as Vayne
Advantage vs Dr. Mundo
True damage ignores Mundo regeneration
Playing as Dr. Mundo
Disadvantage vs Vayne
Silver bolts shred Mundo regardless of regeneration
How to Win This Matchup
Vayne has the advantage in this matchup. If you're playing Vayne, look to press your lead early and deny Dr. Mundo from scaling.
If you're the Dr. Mundo player, play safe early, focus on CS, and look for jungle assistance to turn the lane.
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